When Medications are Prescribed for Type 2 Diabetes Management
When you’re newly diagnosed with type 2 diabetes (T2D), you may be wondering if or when you’ll need medication to manage it and which medications are available to you. Fortunately, there’s a protocol listed in the Diabetes Canada guidelines that health care professionals follow to determine when and what kinds of medications are recommended to help you reach your glycemic goals. In this article, we’ll list the drugs indicated for type 2 diabetes management, as well as when and how doctors are guided towards making the choice to recommend them to patients.
Medications for type 2 diabetes management
- Metformin (biguanides)
- Basal insulin (long-acting insulin)
- Bolus insulin (mealtime/rapid-acting/prandial insulin)
- Mixed insulin
- Thiazolidinediones (TZDs)
- Dipeptidyl peptidase-4 (DPP-4) inhibitors
- Sodium-glucose cotransporter 2 (SGLT-2) inhibitors
- Glucagon-like peptide-1 (GLP-1) receptor agonists
How doctors determine when to prescribe medication
The first line of treatment for type 2 diabetes is with metformin, along with lifestyle modifications. Although metformin’s side effects include gastrointestinal issues such as bloating, abdominal discomfort and diarrhea, this drug is safe and inexpensive and the side effects can be lessened when metformin is taken gradually.
It’s important to remember that type 2 diabetes is a progressive chronic illness, so the treatment with metformin may only work for a few years until another medication is added, at no fault of the patient. Combination therapy allows for patients to reach their A1C targets and sustain their progress.
When A1C is above target, most patients will require some sort of combination therapy, in other words, taking metformin with another medication. The Diabetes Canada guidelines include a chart to help determine when metformin and other medications should be recommended to patients.
The choice of intensifying treatment depends on the preferences of the patient and the progress of their diabetes management, including other health and socioeconomic factors such as:
- Cardiovascular diseases
- Chronic kidney disease
- Other comorbidities
- Potential side effects, safety and tolerability
Also, if a patient isn’t reaching their target goals within three to six months, metformin can be combined with any of these treatments:
- Basal insulin
- GLP-1 RAs
When medications are prescribed for patients with type 2 diabetes and cardiovascular disease or chronic kidney disease
In adults with type 2 diabetes aged 60 years or older with at least two risk factors for cardiovascular disease (CVD), a GLP-1 or an SGLT-2 is recommended independently of A1C or metformin use. These drugs have displayed benefits for patients with CVD and CKD.
How insulin is prescribed
Unfortunately, people within the type 2 diabetes community have been threatened with the prescription of insulin or see the start of insulin therapy as a sign of failure of managing diabetes. But, insulin therapy is an effective way to manage type 2 diabetes and the start of it is never the patient’s fault, but just a sign of type 2 diabetes progression. With that said, it’s important for health care professionals to continually explain the progression of type 2 diabetes.
The kinds of insulins available are:
- Basal (long-acting) insulin
- Bolus (meal-time or rapid-acting) insulin
- Concentrated insulin
- Inhaled insulin
Basal insulin regulates blood glucose overnight and between meals and lasts for 24 hours. This kind of insulin can be added to metformin or used alone. Starting doses are estimated based on body weight, the intensity of hyperglycemia and trial and error based on the patient’s experiences.
Mealtime insulin, also called rapid-acting or prandial insulin, are taken before meals and in addition to basal insulin. To start, a doctor may recommend a dose of four units or 10 percent of the amount of basal insulin and adjust it according to the patient’s needs. Mealtime insulin acts within 15-20 minutes and peaks around two-to-four hours after injections.
Concentrated insulins deliver larger doses of insulin with less volume per milliliter and decrease the number of injections needed at one time for those who need higher doses of insulin. For example, a U-200 insulin pen only requires half the dose of a U-100 pen because it’s twice as concentrated as U-100 insulin. Concentrated insulin pens come in U-200, U-300 and U-500 pens.
Inhaled insulin is used right before or during a meal or used to correct high blood sugar. Its effects are felt rapidly, but this type of insulin is contraindicated in people with lung disease, asthma and pulmonary disease. It’s also not recommended in those who smoke or recently ceased smoking. Patients must take a spirometry test, a test that determines how well your lungs work, before and after starting the use of inhaled insulin therapy.
Can insulin be used with other medications?
Yes. Insulin can be combined with other medications. If basal insulin is having a positive impact on fasting blood glucose but A1C remains above target, then another type of injectable such as a GLP-1 is recommended.
As adults with type 2 diabetes get older, it’s important to simplify complex insulin regimens because of a decreased ability in self-management.
It’s also important to know if you’re being prescribed insulin or any other kind of diabetes medication, your risk of experiencing low blood sugarhypoglycemia increases.
To stay prepared for low blood sugar episodes, your health care provider may advise you to keep a snack or fast-acting carbs on hand and provide a prescription for glucagon, a medication that raises your blood sugar to normal levels, for emergency situations.
While there was only one option for decades—and it was complicated to use—there are more recent and improved emergency glucagon treatment products available in Canada today, including:
- Nasal glucagon – Baqsimi®: This is an emergency glucagon that’s administered through your nose.
- GlucaGen® / GlucaGen® HypoKit: This glucagon comes in the form of a powder that you mix with a liquid and inject into your muscle.
Read all about glucagon, including a step-by-step treatment to administer.
What should I ask my doctor?
If you’re considering different medications to help you manage type 2 diabetes, make sure to speak with your doctor about which medications are best for you and your situation. Take into account the following factors:
- Safety and side effects, including hypoglycemia
- Obtaining a prescription for nasal or auto-injectable glucagon
- Benefits or risks for other health-related issues
- Frequency of dosing
Check out our type 2 guides on oral medications and insulin for more information on how they help with type 2 diabetes management.
Key takeaways on when medications are prescribed:
- Metformin is the first line of treatment at diagnosis.
- Because type 2 diabetes is a progressive chronic illness, metformin may work for few years until another kind of medication is recommended, called combination therapy.
- Combination therapy helps patients reach and sustain their glycemic goals.
- Some medications are recommended because they benefit people at high risk of chronic kidney disease and cardiovascular disease.
- Insulin, such as basal (long-acting) insulin, is recommended due to T2D progression, at no fault of the patient. Other insulins available are bolus (meal-time) insulin, concentrated insulin and inhaled insulin.
- Insulin can be combined with other medications such as a GLP-1 if A1C targets no fault of the patient.
- Remember, the use of medication is never the patient’s fault and should never be used as a threat by health care providers.